Jack R. Harkema

Jack R.  Harkema
  • University Distinguished Professor, The Albert C. and Lois E. Dehn Endowed Chair in Veterinary Medicine, Department of Pathobiology & Diagnostic Investigation
  • Director of the Laboratory for Environmental & Toxicologic Pathology and the Mobile Air Research Laboratories (AirCARE 1 and 2) at Michigan State University
  • Food Safety
  • 1129 Farm Ln Room 212
  • East Lansing MI 48824
  • 517-353-8627


  • Understanding the pathologic basis of health effects caused by environmental and occupational air pollutants
  • Using laboratory animal models of respiratory, cardiovascular, autoimmune and metabolic diseases to explore how chronic diseases affect susceptibility to toxicity caused by inhaled toxicants (ozone, particulate matter and silica dust)
  • With the overall goal to experimentally elucidate cellular, molecular or biochemical targets for interventions to prevent or treat adverse effects caused by air pollution

Current Investigation

  • Role of group 2 innate lymphoid cells (ILC2s) in air pollutant-induced, allergen-independent asthma and rhinitis
  • Mechanisms of dietary lipid prevention/treatment for silica-induced autoimmunity
  • Airway and systemic inflammatory/immune responses to short-and long-term exposures to ambient air pollutants individually or as mixtures


Calvin College, B.S., Biology/Chemistry, 1975 
Michigan State University, M.S., Physiology, 1977
Michigan State University, D.V.M., cum laude, 1980
University of California-Davis, Ph.D., 1985, Comparative Pathology





Dr. Harkema at PubMed

Dr. Harkema at MSU Scholars