Jay I. Goodman

Jay  I. Goodman
  • Professor Emeritus, Department of Pharmacology and Toxicology
  • Food Safety
  • 1129 Farm Ln Room 310
  • East Lansing MI 48824
  • 517-353-9346

RESEARCH INTERESTS

My research interests are focused upon discerning mechanisms underlying the ability of chemicals to cause adverse effects. In particular, I am interested in discerning epigenetic mechanisms that play key roles in the transformation of normal cells into cancer cells and testing the hypothesis that susceptibility to carcinogenesis is related inversely to the capacity to maintain regular patterns of DNA-methylation.  What excites me about research in toxicology is that it combines the theoretical with the practical. While pursuing research aimed at understanding the mechanism(s) of action of the chemical of interest, we learn more about fundamental aspects of biology. Thus, toxicology is a basic biomedical science. On the practical side, the new knowledge gleaned facilitates the enhancement of science-based safety assessment of chemicals. This permits a rational approach towards resolving key issues, e.g., dose-response relationships and appropriate extrapolation from test species to humans. Thus, toxicological research plays a key role by facilitating our ability to safely use chemicals (including, but not limited to, medicines, consumer products and agricultural chemicals) to enhance the quality of people’s lives. Therefore, I view toxicology as “part of the solution.” This is a theme that I began advocating when I was President of the Society of Toxicology (1999-2000).


EDUCATIONAL BACKGROUND

Long Island University, College of Pharmacy, B.S., 1965  
University of Michigan, Ph.D., pharmacology, 1969


AFFILIATED WEBSITES

https://phmtox.msu.edu/people/faculty/goodman/ 


PUBLICATIONS

Dr. Goodman at PubMed

Dr. Goodman at MSU Scholars