Andrea Amalfitano

Andrea  Amalfitano
  • Dean, College of Osteopathic Medicine
  • Osteopathic Heritage Foundation Endowed Professor of Pediatrics
  • Department of Microbiology and Molecular Genetics
  • Fee Hall East Wing
  • 965 Wilson Rd Suite A309
  • East Lansing MI 48824
  • 517-355-9616


One important problem with introduction of genetic material into a living organism is triggering of the innate immune response. Our recent work has now begun to identify key components of the multi-faceted innate immune system, thusly guiding our future efforts to subvert these systems to allow for safer gene transfer. Many of these same systems are also involved in toxic responses to other pathogens as well as to other medicinal or environmental agents, aligning our expertise with that of others in the IIT program.

As we develop our vector technologies, and address the toxicities associated with gene transfer, we have also begun to study the use of these vectors in a variety of clinically important situations. The applications are numerous, thus we have created a number of vectors not only for our use, but also available for use by a number of investigators throughout Michigan State University, as well as for other national/international institutions or corporations. These studies are aimed at determining the ability of gene transfer to prevent, minimize, and/or cure diseases affecting the liver, eye, hearing apparatus, muscles, heart, coronary arteries, as well as its ability to improve certain aspects of cancer therapies.

Our research goals have been, and continue to be, focused upon understanding and utilizing the latest techniques molecular biology has to offer in pursuit of these goals. In such a manner, we will try to bring this knowledge into the clinics, to try and help our patients as quickly as possible.


Michigan State University, B.S., Microbiology, 1984 
Michigan State University, Ph.D., Microbiology, 1989 
Michigan State University, D.O., 1990


College of Natural Science Faculty Profile

MSU Healthcare Profile


Dr. Amalfitano at PubMed

Dr. Amalfitano at MSU Scholars