Skip to main content

Joe Zagorski

Joe ZagorskiCooperating Doctoral Program: CMB

EITS Track: Biomedical Toxicology

Education: B.S. Biotechnology, Purdue University

Research Interests:
Nrf2 is activated by cellular stresses, such as xenobiotics, reactive oxygen species, and electrophiles. Upon activation, Nrf3 will translocate to the nucleus and bind to a sequence known as the antioxidant response element (ARE) in the promoter of its target genes. An increasing number of publications have shown Nrf2 activation to be immune modulatory. Similarly, Nrf2-mice develop a lupus-like autoimmune disease, indicating a potential T cell dysregulation. Our lab has recently shown that activation of Nrf2 by the food additive tBHQ greatly diminishes the production of IL-2 in activated human CD4+ T cells. I am interested in developing a human Nrf2 T cell model, to elucidate the Nrf2 specific effects on the early events of CD4+ T cell activation.

Major Professor: Cheryl Rockwell, Pharmacology and Toxicology