MSU Superfund Program
The MSU Superfund Program has had continuous funding from the National Institute of Environmental Health Sciences Superfund Research Program since 1988. The overall goal of this program is to conduct human health-oriented research on risks from exposure to chemicals commonly found in Superfund sites and on remediation technologies to eliminate the potential for exposure to chemicals from those sites.
The pollutants under investigation are a subclass of chemicals belonging to the halogenated aromatic hydrocarbon family that bind and activate the aryl hydrocarbon receptor (AhR). These chemicals, which include chlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls and polyaromatic hydrocarbons, are environmentally persistent, lipid soluble and accumulate in the food chain leading to human and wildlife exposure.
A highly integrated, multidisciplinary research program is underway consisting of six research projects and six supporting core units. The research team of 22 investigators includes faculty at Michigan State University (16), Rutgers University (2), Emory University (1), Purdue University (1), Texas A&M University (1) and the United States Environmental Protection Agency (1).
The central overarching theme of the program is to define specific aspects of environmental, microbial and mammalian biomolecular responses to environmental contaminants that act as ligands for the AhR. The major research thrusts will provide new mechanistic information in three areas:
- characterizing the diversity and physiogenomic responses of (chloro)dioxin degrading microbial populations indigenous to soils, sediments and groundwater
- defining the geochemical parameters governing adsorbtion, bioavailability and long-term fate of AhR ligands through interactions with geosorbent compositions in soils and sediment components
- elucidation and computational modeling of the interactions of specific biochemical pathways with the ligand-activated AhR which cause altered responses in the liver and immune system with a particular emphasis on responses by human primary cells
One research core will assist the biomedical projects, in developing dynamic computational models of mammalian responses induced by AhR ligands. A second research core will provide bioinformatics support and custom bioinformatics tool development, along with development of a novel molecular method for enriching metagenomes and metatranscriptomes in functional genes of interest to project 4 (biomedical), 5 and 6 (environmental). In addition, a Research Translation Core will communicate research findings to appropriate target audiences in government, industry and academia, a Community Engagement Core will communicate with community target audiences, and a Training Core will provide cross-disciplinary training to pre- and postdoctoral students.
Follow the links to the left to learn more about each of the MSU Superfund Projects and Support Cores.