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Tox Track, 12/1/16

Weekly Newsletter of the MSU Institute for Integrative Toxicology
Director: Dr. Norbert Kaminski / Editor: Lauren St.John

December 1, 2016, Vol. 39, Number 24

Seminars / Workshops / Job Postings

 

Seminars

Friday, December 2
*The Department of Pharmacology and Toxicology presents Dr. Eran Andrechek, to speak on, “Using genomics to predict optimal therapy in a mouse model of breast cancer,” on Friday, December 2, 2016, at 9 a.m. in B448 Life Science Building.

Monday, December 5
*The Department of Fisheries and Wildlife presents Brandon Armstrong, EITS graduate student, to give a dissertation defense seminar on, “Using computational models to scale sublethal effects of stressors to adverse population outcomes in fish,” on Monday, December 5, 2016, at 9:00 a.m. in 338 Natural Resource Building.

Tuesday, December 6
*The Cell and Molecular Biology program presents Sean Nguyen, EITS graduate student, to give a research proposal seminar on, “The Role of Placental Exosomes During Pregnancy,” on Tuesday, December 6, 2016, at 1:00 p.m. in 1425 Biomedical Physical Science Building.

Wednesday, December 14
*The Department of Food Science and Human Nutrition presents Loan Cao, EITS graduate student, to give a research proposal seminar on, “Arsenic and Other Heavy Metals: Concentrations in Apple Juices, Distribution in Orchard Soils and Plant Tissues, and Effects on Human Cells,” on Wednesday, December 14, 2016, at 9:00 a.m. in 206 Trout Building.

Thursday, December 15
*The Comparative Medicine and Integrative Biology Program presents Alexandra Colón-Rodríguez, EITS graduate student, to give a dissertation defense seminar on, “Role of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor on methylmercury-induced calcium dysregulation on motor neurons,” on Thursday, December 15, 2016, at 12:00 p.m. in B448-9 Life Science Building.

*Fulfills seminar requirements for the Environmental and Integrative Toxicological Sciences Graduate Programs. Seminars that fulfill this requirement are archived at: http://cit.msu.edu/training/seminarlist.html.

Workshops

The Graduate School and COGS are co-sponsoring 80 slots for the Write Winning Grant Proposals Workshop offered by the Vice President for Research and Graduate Studies Office. We will pay the $100 registration fee for interested students.  

Because this is a limited opportunity, if you register you must be committed to attending this workshop. Please do not keep another student from attending if you are unsure of your plans.

Your registration must be received by Friday, December 9th at 5:00 PM.

Write Winning Grant Proposals
Thursday, January 5th- 8am-5pm
Molecular Plant Sciences Bldg., Room 1200
John D. Robertson, Ph.D., associate member of the Grant Writers' Seminars and Workshops, LLC Full-day seminar designed for faculty members, graduate students, and administrative staff who want tips and strategies for presenting their research case to reviewers. During the seminar, you will learn more about the practical and conceptual aspects that drive the successful proposal-writing process. 

Learn more about...

  • Idea development
  • Identifying the most appropriate granting agency
  • How to write for reviewers
  • Tips and strategies that are of proven value in presenting an applicant's case to reviewers
  • Strategies for writing proposal sections and examples

Registration required:
$100 fee includes refreshments, lunch, and required workbook.

In order to register you must provide the following in an email to gradwrsp@grd.msu.edu:

**PLEASE INCLUDE “WRITE WINNING GRANT PROPOSALS” IN THE SUBJECT LINE.
1.      Your name
2.      Your department
3.      Your email address
4.      Phone number
5.      Textbook choice (select ONE: NIH, NSF, USDA/NIFA, Any Agency)
6.      Box lunch choice (ham, turkey, veggie wrap or vegan/gluten free)
7.      Do you need any special accommodations? And if so, what?

 

Job Postings

Postdoctoral Position, Office of Research and Development, US EPA

A postdoctoral research opportunity is currently available at the U.S. Environmental Protection Agency’s (EPA) Office of Research and Development (ORD). The appointment will be served with the National Center for Computational Technology (NCCT) in Research Triangle Park, NC.

NCCT is responsible for developing new computational tools and providing quantitative analysis for improving environmental risk assessments and regulatory decisions pertaining to chemical safety and sustainability. NCCT has newly formed an experimental arm with the focus of developing new high-throughput and/or high-content assays as well as exploring increasingly complex cell culture systems that more accurately reflect human physiology. This project aims to develop a library of cell cultures to be readily available for large-scale screening of chemicals and biomolecules for the purpose of performing high-throughput whole genome transcriptomics as well as develop additional complex cell culture systems and analysis techniques for future applications.

The participant will collaborate with a multidisciplinary research team including scientists at EPA and other partners. The participant will be involved in the following activities:

  • developing a library of stable, high quality and reproducible cell cultures
  • developing protocols for chemical and biomolecule screening of these cell cultures with libraries containing hundreds to thousands of test articles
  • developing experimental protocols which support concentration-response assessments of transcriptomic and other cell-based assay endpoints
  • developing complementary in vitro analysis techniques and strategies to aid in chemical screening and targeted follow-up studies
  • developing or adapting complex culture systems for future screening applications.

The participant’s research will be in accordance with a research project plan; guidance will be provided by the research mentor(s). S/he will have latitude in exercising independent initiative and judgment in the research commensurate with the level of training. The ToxCast research program has generated bioactivity data on thousands of chemicals across roughly one thousand assay endpoints. It is recognized that although these assays cover a large swath of biology they are not exhaustive and do not always provide a diverse cellular context. The goals of this project are to develop a diverse collection of in vitro test systems for high-throughput transcriptomic and/or cell phenotypic screening and expand the predictive knowledge-base of in vitro transcriptomic data in support the chemical prioritization and safety assessment process.

The participant will be collaborating with a multidisciplinary research team including scientists at EPA and other partners. A research plan will be developed and the project will be conducted under the guidance of a mentor. The participant will have latitude in exercising independent initiative and judgment in the research commensurate with the level of training.

Through this project, the participant will gain experience in the general areas of cell culture experimentation, high-throughput screening of large chemical libraries, high-content imaging, laboratory robotics, global transcriptomics (specifically RNA-Seq) and other complementary molecular biology techniques. Research findings will be communicated through peer-reviewed publications, national meetings of professional societies, and work-in-progress seminars. The training the participant will receive, coupled with a productive publishing record, should make it possible for them to move into any of these areas or continue down a transdisciplinary career path at their discretion. The research participant will be involved in highly visible predictive toxicology efforts as part of the computational toxicology research projects and will be engaged with researchers world-wide.

This program, administered by ORAU through its contract with the U.S. Department of Energy to manage the Oak Ridge Institute for Science and Education, was established through an interagency agreement between DOE and EPA.

For more information on the position and to apply, please visit: https://www.zintellect.com/Posting/Details/2778.
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Center of Excellence In Environmental Toxicology (CEET)- Program in Environmental Epidemiology – Faculty Positions

The Center of Excellence in Environmental Toxicology at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for several Associate, Full, and/or Assistant Professor positions in the tenure track. Applicants must have an M.D. or Ph.D degree.

Senior faculty applicants should have a research program that links the use of exposure science (exposure assessment, biosensors, biomarkers, geographic information systems, cartographic tools) with diseases of environmental etiology (cancer subtypes, lung and airway disease, metabolic diseases, or developmental basis of adult-disease etc.) Expertise in the epidemiological design of retrospective and prospective studies and the analysis of large data sets is desirable. Individuals at the senior level will have the opportunity to lead this program and significant resources can be made available. Depending on the applicant’s credentials and interests, academic appointments are available in the Department of Biostatistics and Epidemiology, Department of Systems Pharmacology and Translational Therapeutics, Clinical Departments within the School of Medicine and/or the Department of Pediatrics, based in the Children’s Hospital of Philadelphia. Applicants may also be affiliated with the Abramson Cancer Center. Senior applicants (Associate and Full Professor) are expected to have a nationally recognized extramurally funded research program. Junior faculty applicants (Assistant Professor) are expected to have a MD or PhD and several years of postdoctoral epidemiological research experience. At the junior level the applicant must have a disease focus or must be developing new methods for epidemiological studies, and either have grant funding (K-award or equivalent) or should be able to generate their own independent grant support within three years. Applicants should submit their curriculum vitae, names of three references and a description of their current or future research program.

We seek candidates who embrace and reflect diversity in the broadest sense.

For more information and to apply, please visit: https://www.med.upenn.edu/apps/faculty_ad/index.php/d4491.

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Center of Excellence In Environmental Toxicology (CEET)-Translational Research Program in Asthma - Faculty Positions
The Center of Excellence in Environmental Toxicology at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for several Associate, Full, and/or Assistant Professor positions in the tenure track. Applicants must have an M.D./Ph.D degree.

Individuals with a clinical research program in adult or pediatric asthma; or a translational research program working on airway hyper-responsiveness, aberrant lung injury or repair, drug resistance, inhalation toxicology, allergy and immunology, gene-environment interactions or epigenetic therapies are sought. 

Individuals at the senior level have the opportunity to lead this program and significant resources can be made available. Senior applicants (Associate and Full Professor) are expected to have a nationally recognized extramurally funded research program in asthma. Junior Applicants (Assistant Professor) are expected to have a MD/PhD; several years of postdoctoral or clinical research experience and the potential to generate their own grant support. 

The faculty appointment will be in an appropriate department in the Perelman School of Medicine. Depending on the applicant’s credentials, academic appointments are available in the Department of Medicine (within the Divisions of Pulmonary and Critical Care Medicine or Translational Medicine and Human Genetics) in the Department of Systems Pharmacology and Translational Therapeutics or in the Department of Pediatrics, based in the Children’s Hospital of Philadelphia. 

Applicants should submit their CV, names of three references, and a description of their current or future research program online.

We seek candidates who embrace and reflect diversity in the broadest sense.

For more information and to apply, please visit: https://www.med.upenn.edu/apps/faculty_ad/index.php/d4437.


This newsletter is produced and distributed weekly by the Institute for Integrative Toxicology. To be added to the email list or to make suggestions regarding information that might be included in this publication, contact: Lauren St.John, Editor, Institute for Integrative Toxicology, lstjohn@msu.edu.