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Tox Track, 8/22/17

Weekly Newsletter of the MSU Institute for Integrative Toxicology
Director: Dr. Norbert Kaminski / Editor: Lauren St.John

August 22, 2017, Vol. 40, Number 18

Seminars / Events / Workshops & Courses / Call for Members / Job Postings

Seminars

Friday, August 25
*The Department of Pharmacology and Toxicology presents Brittany Winner, EITS graduate student, to give a dissertation defense seminar on, “UCH-L1 as a Susceptibility Factor for Nigrostriatal and Mesolimbic Dopamine Neurons after Neurotoxicant Exposure and Aging,” on Friday, August 25, 2017, at 12 noon in B448 Life Sciences Building.

Friday, September 8
*The Institute for Integrative Toxicology presents Dr. Jon Cook, Chief Toxicology Scientist, Pfizer, to speak on, “Why Toxicologists Should be Trained in Precision Medicine Principles,” on Friday, September 8, 2017, at 12 noon in 162 Food Safety and Toxicology Building.

Wednesday, September 27
*The Department of Pharmacology and Toxicology presents Dr. Ruth A. Roberts, Director and Cofounder, ApconiX, UK and Chair and Director of Drug Discovery and Development, University of Birmingham, to speak on, “Drug Discovery and Development: Challenges and Opportunities,” on Wednesday, September 27, 2017, at 12 noon in B448 Life Sciences Building.

Friday, October 27
*The Department of Pharmacology and Toxicology presents Dr. Frank D. Sistare, Scientific Associate Vice President, Drug Safety, Preclinical Development, Merck & Co, Inc., to speak on, “Aligning Regulatory Agencies and the Pharmaceutical Industry toward Reducing Toxicity Associated Drug Development Costs, Timelines and Attrition: 1) Reducing 2-year Rodent Carcinogenicity Testing, and 2) Deploying Novel Models to Improve Liver Safety Prediction,” on Friday, October 27, 2017, at 9 a.m. in B448 Life Sciences Building.

Friday, November 10
*The Institute for Integrative Toxicology presents Dr. Jason Richardson, Northeast Ohio Medical University, to speak on, “Novel Targets for Reducing Neuroinflammation in Parkinson’s Disease,” on Friday, November 10, 2017, at 12 noon in 162 Food Safety and Toxicology Building.

*Fulfills seminar requirements for the Environmental and Integrative Toxicological Sciences Graduate Programs. Seminars that fulfill this requirement are archived at: http://iit.msu.edu/training/seminarlist.html.

 

Events

MSU Postdoctoral Appreciation Day– Friday, September 15, 2017
Sponsored by the Postdoctoral Association and the MSU Postdoctoral Office

This year we feature an expanded program with an introduction to postdoctoral life at MSU organized in collaboration with the Academic Alliance Network. There will be a Panel Q & A discussion on: strategies to succeed as a postdoc, benefits of being a postdoc, and work-life balance. The event will take place in 1425 BPS. A resource fair and lunch will be held in the MPS Atrium. Please RSVP by September 8, 2017 to pda@grd.msu.edu.

 

Workshops & Courses

FSC 807 Advanced Food Toxicology

Dr. James Pestka, Instructor
Mon/Wed 3:00 – 4:20
Room 1 Trout FSHN
3 credits

*This is a required course for EITS students in the Food Toxicology and Ingredient Safety Track.* 

FSC 807 will focus on the major classes of toxic chemicals in food relative to occurrence, metabolism, molecular/ cellular/ tissue targets, risk assessment and regulation. The course will involve lectures with accompanying readings from texts and recent reviews. In addition, there will be discussions of recent peer-reviewed papers dealing with the occurrence, toxicology and safety assessment of major classes of toxic foodborne chemicals.

Lecture topics will include:

  • Introduction to principles of food toxicology
  • Detection of toxic chemicals in food
  • Absorption, distribution, metabolism and excretion of toxic foodborne chemicals
  • Safety evaluation/Regulation/ of chemicals and use of “FDA Red Book”
  • Food additives
  • Toxicants formed during food processing/packaging
  • Anthropogenic contaminants (eg. pollutants, pesticides)
  • Biological toxins (microbial, plant, animal)
  • Food supplements
  • Food allergens
  • Emerging Issues

Please contact Dr. Pestka at pestka@msu.edu if you have questions about the course.
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PHM 816, Integrative Toxicology: Mechanisms, Pathology and Regulation
*This is a required course for EITS students in the Biomedical Toxicology Track and the Food Toxicology and Ingredient Safety Track.*

PHM 816, Integrative Toxicology: Mechanisms, Pathology and Regulation will be offered this fall MWF, 9 am.

This course covers biochemical, molecular, and physiological mechanisms of toxicology; functional and pathological responses of major organ systems to chemical insult; mechanisms of mutagenesis and carcinogenesis, and concepts in risk and safety assessment.

Students will be expected to attend and participate in class, take written examinations, and give a short oral presenta­tion.

Course moderators this fall are Dr. Jack Harkema and Dr. Patricia Ganey.

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CMSE Bioinformatics Program

The Department of Computational Mathematics, Science and Engineering (CMSE) at MSU is offering Fall 2017 Modular Courses:

CMSE 890 - Sec 301 (Sept 5 - Sept 28): Programming for Bioinformatics
CMSE 890 - Sec 302 (Oct 3 - Oct 26): Statistical Analysis and Visualization
CMSE 890 - Sec 303 (Oct 31 - Nov 28): Transcriptomic Data Analysis


These courses will cover similar material to the August workshops, but will use the flipped-classroom philosophy of having students watch video lectures online and come to class to apply the tools to real data.  They will run from 3:00 - 4:50pm, Tuesdays and Thursdays, in A148A Plant & Soil Sciences Building.  Each module is worth 1 credit.

For more information, please contact: Alexis Black: ablackpz@msu.edu, Arjun Krishnan: arjun@msu.edu, and Jianrong Wang: wangj164@msu.edu

 

Call for Members

Ohio Valley Chapter of SETAC Seeking Interested Students
The Society of Environmental Toxicology and Chemistry (SETAC) is currently looking for students interested in joining the Ohio Valley Chapter (OVC) of SETAC.

Alison M. Pecquet is currently helping the OVC revitalization committee recruit and work with interested students to fill the North America Student Advisory Council (NASAC) position for the OVC. This is a great way for students to become more involved in the society, to make great connections and meet mentors, and to build their resumes.

Please contact Alison for more information:

Alison M. Pecquet
Risk Science Center
Department of Environmental Health
College of Medicine, University of Cincinnati
513-558-6179
Alison.Pecquet@uc.edu


Job Postings

Assistant/Associate Faculty, Department of Pharmacology and Toxicology, University of Utah

The University of Utah is currently recruiting two new faculty members in the Department of Pharmacology and Toxicology. The online posting can be found here: https://utah.peopleadmin.com/postings/67889. The faculty member who shared this posting with MSU, suggested that they have considerable interest in at least one of the hires being a toxicologist with interests in areas that they have specific needs: cardiovascular and immunology, as well as areas where they feel strong collaborations could easily develop. These include pulmonary biology, environmental toxicology, clinical pharmacology (PK/PD), genomics and/or cancer.  Visit the link above to apply.
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Postdoctoral Research Associates, Department of Pathology and Laboratory Medicine, Brown University

Two Postdoctoral Research Associate positions are available immediately in the Department of Pathology and Laboratory Medicine at Brown University in the laboratory of Dr. Kim Boekelheide. 
The candidates will focus on one or more of the following ongoing projects in the laboratory:

One research project, sponsored by the Superfund Research Program (SRP), seeks to identify rat sperm mRNA transcripts and DNA methylation marks that are molecular biomarkers of testicular dysfunction following low-level exposure to cell type specific toxicants and mixtures of toxicants. We will translate these findings by examining sperm molecular biomarkers in an epidemiology study of normal men compared to men treated with methotrexate for autoimmune arthritis. Both genome-wide molecular approaches and morphometric light microscopy are used in combination to study this interdisciplinary research problem focused on mixtures and male reproductive toxicology. The Brown University Superfund Research Program (SRP), "Toxicant Exposures in Rhode Island: Past, Present, and Future" brings together scientists with interdisciplinary training from different backgrounds to work together in a cooperative and synergistic enterprise (See http://www.brown.edu/Research/SRp/). 

A second project sponsored by The Brown University Center to Advance Predictive Biology in response to the release of the landmark report "Toxicity Testing in the 21st Century: A Vision and a Strategy", the U.S. National Academy of Sciences, in 2007, is developing 3-dimensional microtissues for in vitro toxicity testing using high throughput confocal imaging and computational systems biology approaches to identify toxicant-induced alterations in cellular pathways. These new technologies and bioinformatics tools will help shift the paradigm of toxicity testing, characterize the responsible toxicity pathways, and develop a robust mechanistic explanation of toxicant action. 

Successful candidates should have an M.D. or Ph.D. with interest or experience in reproductive biology, toxicology, bioinformatics, image analysis or in vitro techniques. Background training, knowledge and laboratory skills in molecular and cellular biology biochemistry and are required. The initial appointment will be for one year with the intention of extending the appointment if mutually agreeable. Salary is commensurate with NIH guidelines.

Brown University is an EEO/AA employer and invites applications from women and minorities. Candidates should submit a brief statement of previous research experience, curriculum vitae, and contact information for three references to https://apply.interfolio.com/39714.
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Two Postdoctoral Fellowships: Modeling of Harmful Algal Blooms, Cooperative Institute for Great Lakes Research, School for Environment and Sustainability , University of Michigan

Two postdoctoral fellowships are available for highly qualified individuals to join the Cooperative Institute for Great Lakes Research (CIGLR, https://ciglr.seas.umich.edu/) to develop models that help forecast HAB development, transport, and impacts on human health in the Great Lakes. The two postdoctoral fellows will focus on complementary aspects of HAB modeling:

  • The Biophysical Modeler will improve model elements related to algal vertical migration, growth, and toxicity within the FVCOM 3-D forecasting model that drives the Lake Erie HAB-Tracker tool. This position requires a Ph.D. in physical science, biological science, or engineering and a minimum of two years of experience in physical computer modeling, including simulation and analysis of hydrodynamic processes (e.g., FORTRAN-based simulation of currents, water temperature, waves, etc.) and familiarity with a linux/unix parallel modeling environment. Preference will be given to candidates who have a demonstrated ability to perform complex data analysis in a scripting environment using software such as R, Python, IDL, or Matlab, and to quantify uncertainty.
  • The Statistical Modeler will develop new probabilistic models that help predict relationships between nutrient inputs and HAB growth and toxicity, and incorporate approaches for model skill assessment and uncertainty analysis. This position requires a Ph.D. in physical science, biological science, or engineering and experience and experience with data analysis and visualization in a scripting environment using R, Python, or similar software. Preference will be given to candidates that have experience with contemporary statistical modeling approaches (Bayesian networks, causal analysis, hierarchical models, random forests, model averaging), including experience with water quality modeling and nutrient load estimation.

In addition to model development, postdoctoral fellows will assist with field planning, experimental design, and the development and transition of research products to real-time application. Postdocs will be expected to maintain strong records of scholarly publication, as records of presentation at scientific conferences and public meetings.

CIGLR is one of 16 Cooperative Institutes in the United States that represent partnerships between NOAA and academic institutions. Since 1989, CIGLR has been hosted by the University of Michigan in Ann Arbor, Michigan, where it is collocated with its sponsor, NOAA GLERL. CIGLR’s mission is to help government researchers at NOAA GLERL accomplish their research in the Great Lakes by enhancing collaborations with academic scientists at U of M, as well as other institutions throughout the Great Lakes.

The postdoctoral fellowships offer a highly competitive salary with benefits, and the positions will be physically located at NOAA GLERL (https://www.glerl.noaa.gov/) in Ann Arbor, MI, which is routinely ranked as one of the best places to live in the U.S. due to its affordability, natural beauty, preservation of wooded areas, vibrant arts program, and lively downtown landscape.

To apply, applicants should prepare the following materials:

  • Cover letter specifying the position to which you are applying (Biophysical or Statistical Modeler), qualifications related to that position, and research accomplishments.
  • Curriculum vitae
  • Contact information for three professional references
  • Two representative publications

The deadline for applications is September 1, 2017.

Email your application to:

Mary Ogdahl
Program Manager, Cooperative Institute for Great Lakes Research
School for Environment and Sustainability
University of Michigan
ogdahlm@umich.edu  
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Toxicology & Response Manager, State of Michigan
Posted 07/27/2017 – 8/27/2017 - Position is in Lansing, Michigan - Full time with benefits, $35.22 – $50.65/hour

This position is manager of the Toxicology and Response Section and will be responsible for administrative duties including, but not limited to, annual evaluations, time and attendance, performance measures, scorecard metrics, mentoring staff, determining work assignments, recommending disciplinary actions, and ensuring a professional work environment that complies with all state and federal requirements. The section manager is responsible for ensuring the consistent application of the Agency for Toxic Substances and Disease Registration (ATSDR) public health assessment guidance and U.S. Environmental Protection Agency risk assessment guidance. The section manager is responsible for overseeing the work of three units (Drinking Water Investigation, Vapor Intrusion Site Investigation, and ATSDR Site Investigations), MI Toxic hotline, and complex work assignments as assigned by the Division Director. The section manager will directly supervise three unit managers and be responsible for coordinating the work practices across units to ensure consistent application of the best available science and public health practices to protect sensitive and/or vulnerable residents in Michigan. This position works cooperatively with federal, state, and local health and regulatory agencies to address concerns of human exposures to environmental contamination. The person in this position interacts with the public, local, state, and federal officials via meetings, telephone conversations, e-mails, and field visits, responding to community health concerns and providing information to protect public health. This position uses knowledge in toxicology, risk assessment, epidemiology, scientific methods, and public health practice to evaluate and oversee the application of ATSDR and EPA guidance to assess, document, defend, and make public health determinations.

For more details and to apply, please visit: https://www.governmentjobs.com/careers/michigan/jobs/1804357/

This newsletter is produced and distributed weekly by the Institute for Integrative Toxicology. To be added to the email list or to make suggestions regarding information that might be included in this publication, contact: Lauren St.John, Editor, Institute for Integrative Toxicology, lstjohn@msu.edu.