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Tox Track, 5/8/17

Weekly Newsletter of the MSU Institute for Integrative Toxicology
Director: Dr. Norbert Kaminski / Editor: Lauren St.John

May 8, 2017, Vol. 40, Number 10

Seminars / Events / Courses / Workshops / Job Postings

Seminars

Tuesday, May 9
*The Respiratory Research Initiative presents Dr. Wilifred Karmaus, University of Memphis and Dr. Hasan Arshad, University of Southampton, to speak on, “Asthma, eczema and allergies; over the life course and across three generations,” on Tuesday, May 9, 2017, at 11:30 a.m. in 162 Food Safety and Toxicology Building.

Wednesday, May 17
*The Department of Pharmacology and Toxicology presents Rachel Murphy, Ph.D. candidate, Marshall University, to speak on, “Tenofovir Induced Nephrotoxicity: A Mechanistic Study,” on Wednesday, May 17, 2017, at 9:30 a.m. in B448 Life Sciences Building.

*Fulfills seminar requirements for the Environmental and Integrative Toxicological Sciences Graduate Programs. Seminars that fulfill this requirement are archived at: http://iit.msu.edu/training/seminarlist.html.

 

Events

SOT FDA Colloquia on Emerging Toxicological Science: Challenges in Food and Ingredient Safety

A large majority of the public thinks of food safety primarily in terms of either the food or food additives shown on the labels in which they are packaged. However, materials that come in contact with food are also subject to regulation as food additives because the components of these packaging and contact materials may migrate into the food. As the distribution and product protection of food has expanded over a period of decades, highly engineered packaging has evolved to protect foods from contamination and spoilage. In this colloquium, we will focus on the various types of packaging (e.g., coatings, plastics/polymer), manufacturing processes, and safety and exposure assessments.

The first presentation will focus on the regulatory science framework for assessing the safety of food packaging materials and how it is evolving. The second presentation will focus on the materials in key packaging types, such as the plastics and polymers used in bottles, and how they are made and processed. The third presentation will discuss safety considerations and communication. The fourth presentation will focus on migration estimates, i.e., the transfer of chemicals from packaging to the food and estimating dietary exposure. The fifth presentation will discuss the latest innovations and materials used in food packaging.

Safety Assessment of Food Packaging and Other Food Contact Substances
Chair: Charles Barton, Valspar Corporation, Sewickley, PA
Co-Chair: Jason Aungst, US FDA, College Park, MD

May 23, 2017
8:30 AM–12:50 PM ET (GMT-4)
Wiley Auditorium, US FDA, College Park, Maryland


Register for on-site participation by May 15, 2017
Register to participate in the webcast
Colloquium website

The SOT FDA Food Safety Colloquia present scientific training that is high quality, cutting-edge, future-oriented toxicological science for US FDA employees and are open to the public at no cost. However, the colloquia are not a public forum for discussion of toxicology regulatory issues.

Presentations include:

  • US FDA Welcome and Overview of Regulatory Science 
    Michael Adams, US FDA, College Park, MD
  • Overview of Key Packaging and Processing Types 
    Steven Hentges, American Chemistry Council, Washington, DC
  • Can Coatings Primer and Safety Assessment: Communicating Evidence of Absence
    Mark Maier, Sheperian Toxicology, Albuquerque, NM
  • Migration and Exposure Considerations 
    Jessica Cooper, US FDA, College Park, MD
  • Packaging Innovations to Improve Food Safety 
    Maria Rubino, Michigan State University School of Packaging, East Lansing, MI

The event will conclude with a roundtable discussion moderated by colloquium chair, Charles Barton, the speakers and invited speakers from California EPA and Health Canada. Questions from the audience on-site and from those participating in the webcast are encouraged. Jason Aungst, US FDA, is the co-chair of this colloquium.

Recordings and slides from the previous colloquia are available free via the SOT FDA Colloquia website, including the most recent session, March 27, “Considerations for the Determination of Adversity in Food Chemical Safety Evaluations.”
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2017 Great Lakes Chapter Meeting of the American Society of Pharmacology and Experimental Therapeutics, June 23, 2017

It is our great pleasure to invite you to participate in the 2017 meeting of the Great Lakes Chapter of the American Society of Pharmacology and Experimental Therapeutics (GLC ASPET). This meeting will be held on Friday, June 23, 2017 at the University of Illinois in Chicago, Moss Auditorium, College of Medicine Research Building, 909S. Wolcott Ave., Chicago.

This will be our 30th Annual GLC ASPET meeting. Our annual meeting is focused on timely topics in pharmacology and drug discovery, and is designed to promote interactions and build bridges between scientists in the Midwest (e.g., Illinois, Indiana, Iowa, Michigan, Minnesota, Ohio and Wisconsin).  This year’s theme is “Advances in Pharmacoimmunology”.

A major objective of the meeting is to serve as a platform for productive interactions between academic and industrial researchers, as well as suppliers of scientific equipment.  In addition to a poster session (that covers all aspects of pharmacology and life science and that results in awards to the best posters from undergraduate and graduate students, as well as post-doctoral fellows), our scientific sessions will be interspersed with discussions relevant to students interested in a career in pharmacology and drug discovery. 

Abstract deadline is June 9, 2017. Learn more about the event at: https://www.aspet.org/glc/.

 

Courses

Computational Systems Biology and Dose Response Modeling Short Course, PHM 980, Section 301, 1 credit
*Fulfills the EITS Topics in Toxicology requirement*

Date: May 15-17, 2017 (2.5 days)

Location: Food Safety and Toxicology Building, Room 162

Instructors: Sudin Bhattacharya, Michigan State University; Wan-Yun Cheng, US Environmental Protection Agency; Rory B. Conolly, US Environmental Protection Agency; Qiang Zhang, Emory University

Course Description: This short course will cover dynamical systems modeling techniques for quantitative investigation of how biological systems respond to
perturbations at the cellular level. The course will consist of lectures and hands-on computer simulation exercises on:

  • Common network motifs in signal transduction and gene regulatory networks that underlie systems-level cellular behaviors including homeostasis, adaptation, threshold response, binary and irreversible cell fate decisions, and oscillations.
  • How molecular circuits comprimising genes and proteins give rise to various dynamic and dose-response behaviors. Examples include cellular stress response, cell differentiation, and cell cycle and checkpoint control, etc.
  • Use of these simulation techniques to develop computational models for understanding and predicting nonlinear dose response behaviors of environmental toxicants and drugs.

Students will be required to bring a PC laptop computer (Mac is not recommended for compatability issues in some simulation exercises) each day to the course to run computer simulation exercises.

Please contact Dr. Qiang Zhang (qiang.zhang@emory.edu) if you have any course-specific questions.

Please contact Steve Stofflect, stephen.stofflet@hc.msu.edu, in the Department of Pharmacology and Toxicology for course registration/override. NOTE: While the course is offered during the summer semester, you will have to actually enroll in it for fall semester 2017.  

 

 

Workshops

Summer Institute in Data Intensive Biology Workshops, UC Davis
Nine week-long computational workshops will be held at UC Davis from July 10 to July 21.

Week 1: July 10-15

Week 2: July 17-21

All workshops will take place at UC Davis; please see the venue information (http://ivory.idyll.org/dibsi/VENUE.html) for details.

Workshops may extend into the evening hours; please plan on devoting the entire time to the workshop. Workshops are $350/wk.

On-campus housing information is available for approximately $400/wk, which includes breakfast and dinner. Housing registration currently closes April 26th.

Registration links for each workshop are under the workshop description; housing is linked there as well, and must be booked separately. Attendees of both weeks of workshops may book housing for both weeks, and attendees of the two-week introductory bioinformatics workshop, ANGUS (http://ivory.idyll.org/dibsi/ANGUS.html) may book a full four weeks of housing.

For questions about registration, travel, invitation letters, or other general topics, please contact dibsi.training@gmail.com.

For workshop specific questions, contact the instructors (e-mail links are under each workshop).
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13th Summer School on Toxic Compounds in the Environment 2017

RECETOX Research Infrastructure, Regional POPs Centre for Central and Eastern Europe and Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University would like to extend to you an invitation to attend the international 13th Summer School on Toxic Compounds in the Environment 2017, which will commence from 26th June to 30th June 2017 at RECETOX, Masaryk University, Brno, Czech Republic.

For more information please visit: http://www.recetox.muni.cz/

Registration is open here: https://is.muni.cz/obchod/fakulta/sci/recetox/?lang=en

Do not hesitate with registration, summer school is limited to 40 participants.

 

Job Postings

Open Positions, Michigan Department of Health and Human Services, Division of Environmental Health

Considering a career in environmental public health? The Michigan Department of Health and Human Services, Division of Environmental Health has posted three positions:  Health Assessor, Toxicologist, and Environmental Health Scientist. The persons in these positions would be responsible for evaluating environmental data, determining whether a public health hazard exists, and documenting the findings in Health Consultations, Public Health Assessments or other reports. The positions are also responsible for determining whether methods to reduce exposure to chemicals should be recommended. To learn more about the positions, see https://www.mphi.org/careers/. To apply, scroll further down on the webpage for instructions.
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Postdoctoral Position, The Dow Chemical Company

The Toxicology & Environmental Research & Consulting (TERC) group of The Dow Chemical Company (Midland, MI) is looking for a postdoctoral candidate with experience and training in molecular biology, toxicology, bioinformatics or a related emphasis.  The postdoctoral candidate will work closely with TERC scientists and study directors in developing and/or applying state-of-the-art experimental approaches for characterizing toxicity and discerning mode of action. This unique position will present the right candidate with an opportunity to grow and excel in the exciting field of predictive toxicology.

This is a laboratory-based position and the successful candidate is expected to be actively involved in research projects in evaluating bioactivity of compounds using in vitro and Omics approaches and to apply a margin of exposure-based method for safety characterization of chemicals. Activities include experimental design, study conduct, interpretation of results, and evaluation of assay performance. The candidate is expected to present research findings at internal and external workshops/meetings and publish in prestigious peer-reviewed journals. The postdoctoral position at Dow Chemical is for one-year and the contract is renewable up to two years.

Qualifications

  • Ph.D. in toxicology (or related field) with training in molecular biology, bioinformatics is required
  • Experience applying data mining and machine learning algorithms is preferred
  • Strong ability to integrate, analyze and interpret results
  • Works well independently and within a multidisciplinary team setting
  • Excellent communication skills, both oral and written
  • Strong work ethic and attention to detail

For additional details or to apply, contact Dr. Raja Settivari at : RSSettivari@dow.com
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Toxicologist – Senior Scientist, Amway

Reporting to the Manager of Product Safety, Global Technical Services, this Toxicologist will be responsible for leading product safety and risk assessments to support the development of new beauty, personal care and home care products, along with ongoing surveillance of existing products sold globally. This position will lead the safety initiatives for our top brands, offering guidance to enable new product development and promote stewardship in support of our global consumers. The individual will manage the design, monitoring, and interpretation of in vitro and clinical safety studies conducted under Good Clinical Practices (GCP), lead the evaluation of ingredients and formulations for safety purposes, and communicate the recommendations to cross functional teams. This individual will also provide direction on appropriate ingredients, dosages, formulations and processes that will meet regulatory requirements, for safety and quality goals. 

The successful individual will leverage their proficiency to…

  • Ensure safety compliance of cosmetics, personal care and home care products sold globally
  • Lead safety strategy for new product development of cosmetic formulations
  • Contribute to product development teams with data based decisions on ingredient and product safety assessments
  • Design, conduct, and interpret toxicology evaluations and clinical studies on new and existing ingredient formulations
  • Prepare Product Safety Dossier  & safety risk assessment documents, and contribute to regulatory submissions for products in our cosmetic and personal care categories
  • Managing, researching and assessing various product safety related issues and making recommendations regarding possible courses of action
  • Respond to safety-related questions from customers and global teams.

The accomplished individual will possess…

  • Minimum 3 years experience in safety of consumer products or chemicals
  • Strong written and verbal communication skills
  • Knowledge / subject matter expertise on consumer products safety compliance, US and global preferred
  • Experience with toxicity test methods and risk assessments for consumer products
  • Ability to offer thought leadership on strategic safety recommendations
  • Analytical talent to recognize and communicate implications of emerging safety/regulatory issues
  • Talent to lead project teams offering influence with tact and diplomacy
  • Knowledge of product development processes and background offering safety support in product development
  • Ability to prioritize in a fast paced environment demonstrating commitment to goals

The strong professional will have the following academic credentials ….

  • PhD with 3 - 5 yrs industry experience in Toxicology, Pharmacy, Medicine or related discipline.
  • Board certified toxicologist desired

Amway’s exceptional benefits package includes: Medical, dental, prescription and vision insurance; 401(K) participation; Profit Sharing; Bonus Eligibility; Fitness Center; product discounts.  Look into how Amway can transform your career!  Visit our web site to apply: www.amway.jobs.
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Senior Analyst, American Beverage Association

The American Beverage Association (ABA) is the trade association that represents America's non-alcoholic beverage industry. ABA was founded in 1919 as the American Bottlers of Carbonated Beverages, and renamed the National Soft Drink Association in 1966. Today the ABA represents hundreds of beverage producers, distributors, franchise companies and support industries.

Together, they bring to market hundreds of brands, flavors and packages, including regular and diet soft drinks, bottles water and water beverages, 100 percent juice and juice drinks, sports drinks, energy drinks and ready-to-drink teas.

Position
The Senior Analyst, Science Research is responsible for advancing ABA’s Science Research priorities with key emphasis on nutrition and ingredient safety.

  • Monitor the scientific landscape (both tox and nutrition) relative to both the safety of the ingredients our beverage companies use and the efficacy of our products (emerging issues);
  • Serve as VP's surrogate at conferences;
  • Draft regular outlook/updates summarizing findings from key “quality” studies (and studies presented at conferences) and highlight significance;
  • Help create a user-friendly electronic database to house the available literature, registered studies (e.g., ClinicalTrials.gov) and other sources of information that would help quickly identify relevant publications as basis for science-based positions.

Importantly, this position will require significant review of research articles that reflect toxicological concepts, epidemiology, nutrition, statistics, etc. coupled with distillation of key points. Being computer/software savvy to help create and maintain a searchable electronic filing system is desired.

Qualifications: To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Education and/or Experience: To be qualified for this position, the individual must possess a M.S. or equivalent degree is required with a minimum of 2 years related work experience within Public Health, Environmental Science, and Biology, Toxicology and/or Chemistry and at least one of these: Nutrition, Ingredient Safety, Contaminants.

For more information and to apply, please contact:
Maia M. Jack, Ph.D.
Vice President, Science and Regulatory Affairs
American Beverage Association
mjack@ameribev.org
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Faculty – Assistant or Associate Professor, Tenure Track, Columbia University
Field of Specialization:  Toxicology
Proposed Starting Date:  July 1, 2017

Position Description:  The Department of Environmental Health Sciences of Columbia University’s Mailman School of Public Health seeks applicants for 1-2 tenure track faculty positions at the level of Assistant or Associate Professor, beginning July 1, 2017.  We seek scholars with a doctorate degree in Toxicology and are particularly, but not exclusively, interested in expertise in neurotoxicology.  We are also interested in scientists working on the microbiome as it relates to environmentally-induced diseases.  The successful candidate(s) will work and collaborate with investigators across the Columbia University Medical Center to develop a comprehensive research program in the areas referenced above, and she/he will play a substantial role in our MS, MPH and PhD educational programs as a teacher and mentor.

Minimum Degree Required:  Doctoral degree, terminal professional

Minimum Qualifications:  Doctorate degree in toxicology, neurotoxicology, environmental health sciences, or other related discipline (PhD, ScD, DrPH or MD), with substantial post-doctoral training and experience in mechanisms of environmental disease, or cellular, molecular or in vivo models of human disease.  A strong publication record, original and creative long-term research vision and demonstrated excellence in teaching and mentoring are required.  A record of obtaining peer-reviewed funding for independent research is essential, as is a demonstrated success in working with multidisciplinary and multi-institutional teams.

Applicants should submit a cover letter, CV, personal research plan, statement of teaching philosophy, and list of references to the attention of Dr. Joseph Graziano, Search Committee Chair, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 West 168th Street New York, NY 10032 using the following link https://academicjobs.columbia.edu/applicants

This newsletter is produced and distributed weekly by the Institute for Integrative Toxicology. To be added to the email list or to make suggestions regarding information that might be included in this publication, contact: Lauren St.John, Editor, Institute for Integrative Toxicology, lstjohn@msu.edu.