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John L. Goudreau

John GoudreauDirector, Translational Neurobiology Research Unit; Associate Professor, Pharmacology and Toxicology; Associate Professor, Neurology.


Research Interests:
My research interests are focused on genetic and environmental factors involved in the pathogenesis of neurodegenerative disorders such as Parkinson's Disease (PD). PD is a progressive illness characterized by resting tremor, slowness and stiffness of movement in addition to problems with balance and walking. PD is a common disease, affecting nearly 1 million people in the United States. The cause of PD is unknown, but combinations of both genetic and environmental factors are thought to play an important role.

The work in my laboratory involves using rodent models to identify and characterize genetic and environmental factors that may lead to PD. Selective neurotoxin exposure, alone or in combination with transgenic or knockout animals are used to test the importance of environmental and genetic factors. Animals will be evaluated on the basis of their motor behavior in combination with neurochemical, pathological, and immunohistochemical changes in selected regions of the brain. In addition, genome-wide mRNA expression profiling is used to identify changes in expected and novel gene expression. Novel potential candidate genes will be screened for disease-prodisposing polymorphisms in patients with PD.

Educational Background:
Michigan State University , B.S., 1988, Medical Technology
Michigan State University, B.A., 1988, Chemistry
Michigan State University , Ph.D., 1994, Neuropharmacology
Michigan State University, D.O., 1995, Medicine

Selected Professional Activities:
Dr. Goudreau is a past recipient of the Mayo Brothers Distinguished Fellowship Award from the Mayo Clinic and also received an Honors Fellowship from the MSU Medical Scientist Training Program. Dr. Goudreau is ABMS board certified from the American Board of Neurology and Psychiatry. He serves on the professional advisory board for the Michigan Parkinson Foundation and was the Chair of the COMLEX Level 1 Committee for the National Board of Osteopathic Medical Examiners.


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