Alison I. Bernstein
Assistant Professor, Translational Science and Molecular Medicine
Van Andel Institute
333 Bostwick Ave Ne Ste Phase 2
Grand Rapids MI 49503 US
Research in the Bernstein lab focuses on how epigenetic modifications mediate neurotoxicological effects and gene-environment interactions underlying sporadic neurodegenerative diseases. Although these diseases are generally diseases of the aged, the neurodegenerative process begins long before clinical diagnosis. Thus, exposures that occur early in life may contribute to sporadic forms of disease by directly affecting the vulnerability of neurological systems. Epigenetic modifications are thought to imprint environmental experiences on the genome, resulting in stable alterations in phenotype. Thus, linking epigenetic changes with functional outcomes will help to elucidate the mechanisms underlying sporadic neurodegenerative diseases and further our understanding of the complex relationship between toxicity, epigenetics and neuronal vulnerability. Currently, there are two major projects in the lab.
Epigenetics in Parkinson’s disease
This project aims to characterize the epigenetic changes that occur in PD by analyzing genome-wide DNA modifications (5-methylcytosine and 5-hydroxymethylcytosine) from post-mortem brain tissue from control samples and both early and late stage PD samples. By combining epigenetic analysis with transcriptome analysis, gene networks that contribute to the risk of PD can be identified.
Epigenetics in toxicant models of Parkinson’s disease
Exposure to various compounds (e.g. organochlorine pesticides, flame retardants, caffeine, nicotine) has been shown to modify risk of Parkinson’s disease. Characterization of the epigenetic changes that occur in acute and developmental exposure models, combined with tests of dopaminergic function and vulnerability to future insults, will begin to reveal how epigenetics mediates the response to environmental exposures and contributes to the risk of PD.
University of Pennsylvania, B.A., 2000, Biological Basis of Behavior
Washington University in St. Louis, Ph.D., 2009, Molecular Genetics and Genomics
Emory University, Postdoc, 2009-2016, Neuroscience, Neuroepigenetics, Neurotoxicology