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Andrea Amalfitano

Andrea AmalfitanoProfessor, Microbiology and Molecular Genetics; and Pediatrics; Osteopathic Heritage Foundation Endowed Chair


Research Interests:
One important problem with introduction of genetic material into a living organism is triggering of the innate immune response. Our recent work has now begun to identify key components of the multi-faceted innate immune system, thusly guiding our future efforts to subvert these systems to allow for safer gene transfer. Many of these same systems are also involved in toxic responses to other pathogens as well as to other medicinal or environmental agents, aligning our expertise with that of others in the IIT program.

As we develop our vector technologies, and address the toxicities associated with gene transfer, we have also begun to study the use of these vectors in a variety of clinically important situations. The applications are numerous, thus we have created a number of vectors not only for our use, but also available for use by a number of investigators throughout Michigan State University, as well as for other national/international institutions or corporations. These studies are aimed at determining the ability of gene transfer to prevent, minimize, and/or cure diseases affecting the liver, eye, hearing apparatus, muscles, heart, coronary arteries, as well as its ability to improve certain aspects of cancer therapies.

Our research goals have been, and continue to be, focused upon understanding and utilizing the latest techniques molecular biology has to offer in pursuit of these goals. In such a manner, we will try to bring this knowledge into the clinics, to try and help our patients as quickly as possible.

Educational Background:
Michigan State University, B.S., Microbiology, 1984
Michigan State University, Ph.D., Microbiology, 1989
Michigan State University, D.O., 1990

Selected Professional Activities:
Dr. Amalfitano was the 2001 recipient of the MSU College of Osteopathic Medicine's Alumnus of the Year Award. He completed his pediatrics residency at the Mayo Clinic and also completed fellowships at the University of Michigan Medical Center. Subsequently, he was an Assistant and Associate (tenured) Professor of Microbiology and Molecular Genetics, Pathology, and Pediatrics at Duke University Medical Center. He was honored with the 1997-1998 James Shannon Award, from the National Institutes of Health, while at Duke University for "Adenovirus vectors for Gene Therapy." Dr. Amalfitano was acting Chief of the division of Medical Genetics just prior to returning to his alma mater, Michigan State University. Dr. Amalfitano is board certified by the American Board of Medical Genetics. He belongs to the American Society of Gene Therapy, the American Society of Gene Therapy, the American Society of Microbiology, and the European Society of Gene Therapy.


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Laboratory Trainees:

  • Sergey S. Seregin, Postdoctoral, Microbiology and Molecular Genetics
  • Yasser Ali Aldhamen, Postdoctoral, Microbiology and Molecular Genetics
  • Nathan Schuldt, Postdoctoral, Microbiology and Molecular Genetics
  • Dionisia Quiroga, Predoctoral, Osteopathic Medicine/MSTP
  • David P. Rastall, Predoctoral, Osteopathic Medicine/MSTP